SciChart WPF v4.2.1 should support .NET Framework versions 4.0 and up. It is not tested on later versions of .NET Framework such as .NET 5, .NET 6.
Please be aware SciChart WPF v4, v5 has a licensing mechanism which is going end of life soon. It is advisable to upgrade to SciChart WPF v6 as soon as possible if you are still using it.
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